Epidermolysis Bullosa is a genetic disease. The disease may be passed on from one parent who has the disease, which we call autosomal dominant inheritance, or it may be passed on from both parents (autosomal recessive inheritance) or it came as a new mutation that rose in the affected person that can be passed on to their next kin.
The skin is made up of an outer layer (epidermis) and an underlying layer (dermis). The area where the skin meet is called the junctional zone. At least 15 types of skin proteins are gluing them together. Some of them are;
Epidermolysis Bullosa can result from a genetic mutation in one of the 18 genes. These mutations, or errors in the genetic code, do not allow the body to either produce a protein that is essential, or produce a working form of the protein, thus resulting in in extremely fragile skin. EB can also be an autoimmune disease, in which the body produces antibodies to the structural components of the skin.