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In this type, blistering occurs in the upper layer of the skin called the epidermis. It is characterised by a lack of adhesion of the skin directly above the basement membrane (the basal layer). EBS is the most common type of EB, and is held accountable for 70 percent of cases. EBS is generally milder than other types of EB, although the blistering is painful and easily compounded by rubbing.
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EBS usually is inherited in an autosomal dominan manner, meaning that a defective gene inherited from a parent is enough to develop the condition.
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The blistering may develop either on the hands or the feet (localised EBS) or all over the body (generalised EBS).